Emily Edmunds has a great job and a great guy, Mark. But when Mark is killed in a plane crash, a distraught Emily attempts suicide. Her psychiatrist, Dr. Thorne, manages to pull her out of her catatonic state. It soon becomes clear that Dr. Thorne is fixated on Emily, who bears a strong resemblance to Thorne's daughter who was in a terrible accident some years before. When Emily is kidnapped by Dr. Thorne, Emily must find a way to defeat a woman who knows her every weakness.

Nathan, a brilliant New York lawyer who leads a life of professional success, but his private life is pretty dismal since he divorced Claire, his only love. Until he meets Doctor Kay, a mysterious doctor who introduces himself as a "Messenger." He claims that he can sense when certain people are about to die, and that he is sent to help them put their life in order before it's too late. Nathan doesn't believe a word of this, but soon afterwards he witnesses some disconcerting scenes which seem to confirm the doctor's claims.

In Boston, there is an unknown epidemic and the population is consuming the Hydropure water and vegetables from Whitefield Corporation. The City Hall Secretary, Taylor Lambert, contacts a newspaper journalist, Lisa Wallace, expecting to give evidence of a conspiracy that his partner Connie is collecting. However, Glenda is captured and murdered by the guards, and Lambert shoots the Mayor and takes a sample of his blood to give to Lisa. Lambert is hunted and wounded by the police. He meets the journalist, Ben Mosher, who writes for the sensationalist column 'Mystery Science' in the same newspaper. Lambert gives Ben a vial with the Major's blood before he dies and Ben gives the sample to his friend Knutt Jourgensen for analysis.